STAT-6-Mediated Control of P-Selectin by Substance P and Interleukin-4 in Human Dermal Endothelial Cells
نویسندگان
چکیده
منابع مشابه
Regulation of substance P mRNA expression in human dermal microvascular endothelial cells.
Vascular endothelial cells have been identified as a source of substance P (SP) which may act in an autocrine/paracrine fashion to bring about nitric oxide (NO)-dependent vasodilatation and mitogen-induced cell division or immunologic and inflammatory responses. Whilst SP is localised in and released from endothelial cells, an endothelial mRNA expression of SP has not previously been shown. In ...
متن کاملInterleukin 4 or oncostatin M induces a prolonged increase in P- selectin mRNA and protein in human endothelial cells
During acute inflammation, P-selectin is transiently mobilized from Weibel-Palade bodies to the surface of histamine-activated endothelial cells, where it mediates rolling adhesion of neutrophils under hydrodynamic flow. During chronic or allergic inflammation, sustained expression of P-selectin on the endothelial cell surface has been observed. We found that the cytokines interleukin 4 (IL-4) ...
متن کاملStat6 activation is essential for interleukin-4 induction of P-selectin transcription in human umbilical vein endothelial cells.
Chronic upregulation of P-selectin expression on the surface of the endothelium has been observed in and likely contributes to a number of chronic inflammatory diseases, including atherosclerosis. Agonists of P-selectin expression fall into 2 categories: those that induce a very rapid, transient increase, lasting only hours, and those that induce prolonged upregulation lasting days. It is the l...
متن کاملChronic expression of P-selectin on endothelial cells stimulated by the T-cell cytokine, interleukin-3.
P-selectin expressed on the surface of endothelium mediates leukocyte adhesion in vitro and rolling in vivo. Several inducers of cell-surface P-selectin expression on endothelial cells (EC) have previously been identified, all of which yield transient cell-surface expression of P-selectin lasting minutes to a few hours. We now show that a T-lymphocyte product, interleukin-3 (IL-3), stimulates t...
متن کاملDimerization of P-selectin in platelets and endothelial cells.
P-selectin is a leukocyte adhesion receptor stored in platelets and endothelial cells and is translocated to the surface upon cell activation. Purified P-selectin is oligomeric and has increased avidity for its ligand relative to the monomeric form, but whether P-selectin self-associates in the membrane of intact cells is not known. A chemical cross-linking approach was used to show that P-sele...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2006
ISSN: 0002-9440
DOI: 10.2353/ajpath.2006.051211